American Peptide Symposium Poster Describes Synthesis of Hydrocarbon-Stapled Peptides
Released on = July 12, 2007, 8:36 am
Press Release Author = AnaSpec Inc.
Industry = Biotech
Press Release Summary = At the 2007 annual conference of the American Peptide Society, AnaSpec presented a technical poster that described the facile synthesis of a hydrocarbon-stapled peptide. Asymmetric synthesis of (S)-Fmoc-α-(2'-pentenyl)-alanine was successfully accomplished via an Ala-Ni (II)-BPB-complex [3] in three steps with a 40% total yield.
Press Release Body = July 10, 2007 - Montreal, QC, Canada
At the 2007 annual conference of the American Peptide Society, AnaSpec presented a technical poster that described the facile synthesis of a hydrocarbon-stapled peptide. Asymmetric synthesis of (S)-Fmoc-α-(2'-pentenyl)-alanine was successfully accomplished via an Ala-Ni (II)-BPB-complex [3] in three steps with a 40% total yield.
The modified hydrocarbon-stapled peptides are helical, relatively protease-resistant, and cell-permeable peptides that bind with increased affinity for its target, and may provide a useful strategy for experimental and therapeutic modulation of protein-protein interactions in many signaling pathways.
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Company Info AnaSpec, Inc. is a leading provider of integrated proteomics solutions to pharmaceutical, biotech, and academic research institutions throughout the world. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry. Established in 1993, AnaSpec\'s headquarters and manufacturing facilities are located in San Jose, CA.
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